On my Xbox I'm trying to get the wife into Beyond Good & Evil. It is exactly the type of game she normally loves, but for whatever reason she just isn't gelling with it. I've played and beaten the game before, and I would love to play it again, but if she isn't going to watch me play it then I probably won't, as I'm also playing Darkwatch and Advent Rising.
On the 360 I'm playing... well, nothing until I get GRAW and/or Fight Night 3. Oh, I am playing some Geometry Wars Retro Evolved and Hexic!
On the PS2 I'm still trying to finish Ico and Shadow Of The Colossus.
On my DS I'm playing Castlevania: Harmony Of Dissonance, and it is AWESOME!